Hormonal contraceptive with anti mineral corticoid and antiandrogene effect: efficacy and tolerance

Prilepskaya V.N., Ostreykova L.I .

Research Centre of Obstetrics, Gynecology and Perinatology, Moscow, Russia

Combined oral contraceptive Yarina (Yasmin) containing 0.03 mg ethynilestradiol and 3 mg new gestagen drospirenon is a novel stage in hormonal contraception. Drospirenon is a derivative of 17-alpha-spironolacton and in some features is similar to it. Due to unique antimineralcorticoid and antiandrogene effects the use of Yarina arrests eodema in an organism and thus improves the tolerance of hormonal contraception.

Objectives: Analysis of efficacy and tolerance of oral contraceptive Yarina in women of reproductive age.

Materials and methods: 68 women, aged 18 to 39 (mean age 24 +/- 3.2) without any contraindications to hormonal contraception. Follow-up period was 12 months. All patients were examined with clinical methods and Pape smear test. All women were requested to keep menstrual daybook.

Results: At initial examination 19 patients demonstrated the symptoms of premenstrual syndrome. Subjective and objective status of patients was assessed according to specially elaborated questionnaire. All patients were noted to have the signs of irritation on days 4 - 10 prior to menstrual onset, 4 had depressive status, headaches, oedema was noted in 15 cases. No patient was registered to conceive during contraception. Intramenstrual bleedings were found in 2 women, vomiting in one. Decrease or elimination of premenstrual symptoms were detected in 14 out of 15 patients.

Conclusion: Yarina is highly effective contraceptive. It is generally well tolerated, achieving good cycle control and having beneficial effects on acne and other skin-related conditions. There is evidence to suggest that Yarina has a beneficial effect in the treatment of premenstrual syndrome as well as having a positive effect on well-being and health-related quality of life. Overall, Yarina is a promising treatment option for women requiring contraception.